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Effects of reserpine and chlorpromazine on 5-hydroxytryptamine uptake of platelets from migrainous and control subjects
  1. Barbara P. Hilton
  1. Department of Neurochemistry, Institute of Neurology, National Hospital, Queen Square, London

    Abstract

    Platelet aggregation experiments confirm differences between the 5-hydroxytryptamine (5-HT) receptors of migrainous and control platelets. However, no differences have been found in 5-HT uptake, in the presence of reserpine or chlorpromazine, into migrainous and control platelets. The results support the hypothesis that receptors for 5-HT induced platelet aggregation provide a model for vascular receptors causing constriction and are distinct from those transferring 5-HT through the platelet membrane.

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