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Subacute brain-stem encephalitis
  1. S. G. Waxman1,
  2. T. D. Sabin,
  3. L. J. Embree
  1. Neurological Unit, Boston City Hospital, Boston, Massachusetts, U.S.A.
  2. The Mallory Institute of Pathology, Boston City Hospital, Boston, Massachusetts, U.S.A.
  3. Department of Neurology, Boston, Massachusetts, U.S.A.
  4. Department of Harvard Medical School, Boston, Massachusetts, U.S.A.
  5. Department of Tufts Medical School, Boston, Massachusetts, U.S.A.

    Abstract

    A 65 year old man developed progressive signs of pontine and medullary dysfunction with striking bilateral paralysis of lateral gaze, dysarthria, dysphagia, and ataxia. A respiratory death occurred seven months from the onset. Pathological examination revealed focal brain-stem changes of perivascular lymphocytic cuffing, microglial infiltration, glial nodules, and neuronophagia. No underlying malignancy or general disease impairing immunity mechanisms was discovered.

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    Footnotes

    • 1 Address for correspondence: Dr Stephen Waxman, Neurological Unit (Medical 9), Boston City Hospital, 818 Harrison Avenue, Boston, Massachusetts 02118, U.S.A.

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