A case is reported of a 34 year old white male with chronic renal failure secondary to glomerulonephritis who received four renal transplants over a period of five years. He died 25 months after the fourth transplant. Necropsy revealed a reticulum cell sarcoma-microglioma of the brain. The possibility that multiple transplants may have had a synergistic effect in the development of a malignant cerebral lymphoma in this patient is briefly discussed in the light of the current theories concerning the pathogenesis of the tumours in transplant recipients and in the context of the present therapeutic approach to graft rejection.
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↵1 Supported by Graduate Neuropathology Training Grant 5T01 NS 05500-08, from the National Institute of Neurological Diseases and Stroke, and Grants CA-08122 and CA-05838 from the National Cancer Institute, U.S.P.H.S.
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