Loss of vestibulo-ocular reflexes occurred in two patients with acute supratentorial lesions who received therapeutic doses of anticonvulsant drugs. There was no clinical or angiographic evidence of focal brain-stem damage. Absence of vestibulo-ocular reflexes is attributed to a combination of acute cerebral damage and anticonvulsant drugs. The loss of these reflexes in patients with acute cerebral lesions cannot be interpreted as evidence of irreversible brain-stem injury.
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↵2 Reprint requests: Dr M. A. Rosenberg, University of Illinois Eye and Ear Infirmary, 1855 W. Taylor St., Chicago, Illinois, U.S.A. (Accepted 17 June 1974).
↵1 This work was supported in part by a Heed Ophthalmic Foundation Grant (M. Rosenberg); Ontario Ministry of Health Fellowship (J. Sharpe); and U.S.P.H.S. N.I.H. Training Grant EY 00083-02 (W.F. Hoyt).
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