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Dopamine correlates of neurological and psychological status in untreated Parkinsonism
  1. Margaret M. Hoehn,
  2. T. J. Crowley,
  3. C. O. Rutledge
  1. Department of Neurology, University of Colorado Medical Center, Denver, Colorado, USA
  2. Department of Psychiatry, University of Colorado Medical Center, Denver, Colorado, USA
  3. Department of Pharmacology, University of Colorado Medical Center, Denver, Colorado, USA

    Abstract

    Thirty-seven untreated Parkinsonism patients showed significant positive correlations among decreased excretion of free dopamine, MMPI scores indicative of schizophrenic-like looseness of thinking, and the severity of all Parkinsonism signs except tremor. The data could indicate that abnormalities of dopamine metabolism may underlie both the motor and mental abnormalities of Parkinsonism.

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    Footnotes

    • 1 Supported by US Public Health Service—National Institutes of Health Grant NS 09199 and Grant (RR-51) from the General Clinical Research Program of the Division of Research Resources, National Institutes of Health.

      Present address: Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, Kansas 66045, USA.

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