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Acute conduction velocity changes in guinea-pigs after administration of diphenylhydantoin
  1. Pamela M. Le Quesne,
  2. Valerie Goldberg,
  3. F. Vajda
  1. Medical Research Council Toxicology Unit, Carshalton Surrey
  2. The Department of Neurological Studies, The Middlesex Hospital, London
  3. The Department of Pharmacology, The Middlesex Hospital, London
  4. The Department of Chemical Pathology, Institute of Neurology, Queen Square, London

    Abstract

    Motor nerve conduction velocity was measured after dosing guinea-pigs with 200-400 μmol/kg diphenylhydantoin (DPH) daily for three to four days. Conduction velocity fell by a mean value of 13% in animals that achieved plasma DPH levels over 200 μmol/l. There was no change in velocity with DPH levels below this value.

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