Article Text

PDF

Double-blind clinical trial of 5-hydroxytryptophan in a case of Lesch-Nyhan syndrome.
  1. C D Frith,
  2. E C Johnston,
  3. M H Joseph,
  4. R J Powell,
  5. R W Watts

    Abstract

    5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significant reduction of athetoid movement and a sedative effect but did not improve the patient's mood or reduce self-mutilation.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.