Article Text


Double-blind clinical trial of 5-hydroxytryptophan in a case of Lesch-Nyhan syndrome.
  1. C D Frith,
  2. E C Johnston,
  3. M H Joseph,
  4. R J Powell,
  5. R W Watts


    5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significant reduction of athetoid movement and a sedative effect but did not improve the patient's mood or reduce self-mutilation.

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