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Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants.
  1. R A Shakir,
  2. P O Behan,
  3. H Dick,
  4. D G Lambie

    Abstract

    Low serum IgA levels were found in patients taking phenytoin, together with evidence of depressed T cell function. There was no correlation between the dose or the serum level. A correlation was found, however, with HL-A status, patients with a low IgA showing increased frequency of HL-A2. It is suggested that epileptic patients with HL-A2 status are likely to develop IgA deficiency when given phenytoin.

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