Anti-acetylcholine receptor (AChR) antibodies have been determined in the sera of ten myasthenic patients over a period of several months which in each case included a series of plasma-exchanges coupled with immunosuppressive therapy. The ratio of anti-(extra-junctional rat AChR): anti-(human AChR) antibody titres was found to vary with the patient but to be constant for a given patient over the period of study. Similar indications of a patient-specific anti-AChR antibody pattern were obtained by using junctional as well as extra-junctional rat AChR and also by precipitation of human AChR in the presence of excess antiserum. Individual anti-AChR antibody patterns may have relevance to the varying courses taken by myasthenia gravis in different patients.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.