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Rectal diazepam in the treatment of absence status: a pharmacodynamic study
  1. Norman Milligan*,
  2. Soraya Dhillon,
  3. Alan Richens,
  4. Jolyon Oxley
  1. *Institute of Neurology, Queen Square, London
  2. Department of Pharmacology and Materia Medica, Welsh National School of Medicine, Cardiff
  3. The ‡Chalfont Centre for Epilepsy, Chalfont St Peter, Gerrards Cross, Bucks

    Abstract

    Rectal administration of diazepam is highly effective in terminating absence status as judged by reduction of spike-wave activity in the EEG. Pharmacokinetic studies indicate that diazepam can have antiepileptic properties at serum levels well below those previously reported as being necessary to achieve a therapeutic effect.

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