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Panencephalopathic type of Creutzfeldt-Jakob disease: primary involvement of the cerebral white matter
  1. Toshio Mizutani*,
  2. Atsushi Okumura,
  3. Masaya Oda,
  4. Hirotsugu Shiraki§
  1. *Clinical Neuropathology, Tokyo Metropolitan Institute for Neurosciences, Fuchu, Japan
  2. The Department of Psychiatry, School of Medicine, Osaka City University,† Japan
  3. The Department of Neuropathology, Institute of Brain Research, School of Medicine, University of Tokyo,‡ Japan
  4. §The Shiraki Institute of Neuropathology, Tokyo, Japan§

    Abstract

    Eight necropsy cases of a “panencephalopathic” type of Creutzfeldt-Jakob disease (CJD) in the Japanese are reported. The reasons why this type should be discussed separately from other types of CJD are that there is primary involvement of the cerebral white matter as well as the cerebral cortex, and that the white matter lesion of one Japanese human brain with CJD similar to the present group has been successfully transmitted to experimental animals.

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