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J Neurol Neurosurg Psychiatry 1981;44:329-333 doi:10.1136/jnnp.44.4.329
  • Research Article

The clinical relevance of ferritin concentration in the cerebrospinal fluid.

  1. C J Sindic,
  2. D Collet-Cassart,
  3. C L Cambiaso,
  4. P L Masson,
  5. E C Laterre

      Abstract

      By means of a new technique (Particle Counting Immunoassay), we have determined the level of ferritin in 470 samples of cerebrospinal fluid of patients with various neurological disorders. The median value obtained in a control group was 2.3 ng/ml with an upper limit at 5.5 ng/ml. the concentrations in the serum and cerebrospinal fluid were independent, but that in cerebrospinal fluid correlated with its total protein content. High values of ferritin were found in infectious meningo-encephalitis, in vascular diseases of the central nervous system, and, unexpectedly, in several cases of dementia without obvious vascular pathology.

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