J Neurol Neurosurg Psychiatry 45:143-146 doi:10.1136/jnnp.45.2.143
  • Articles

Direct demonstration of transsynaptic degeneration in the human visual system: a comparison of retrograde and anterograde changes

  1. RM Beatty,
  2. AA Sadun,
  3. LEH Smith,
  4. JP Vonsattel,
  5. EP Richardson, Jr
  1. CS Kubik Laboratory for Neuropathology, Department of Pathology, Massachusetts General Hospital, the Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, and the Departments of Neurology-Neuropathology, Pathology, and Ophthalmology, Harvard Medical School, Boston, Mass, USA


      Transneuronal degeneration of retinal ganglion cells was directly demonstrated in a patient who had unilateral removal of the striate cortex forty years prior to necropsy. For comparison, another case is presented showing anterograde transneuronal atrophy forty years after enucleation of one eye.