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Effect of chain length of short-chain fatty acids on their effect on intracranial pressure in rabbits
  1. Doris A Trauner,
  2. Heather Adams
  1. Department of Neurosciences, University of California School of Medicine, La Jolla, California, USA
  2. Department of Pediatrics, University of California School of Medicine, La Jolla, California, USA

    Abstract

    The short-chain fatty acids propionic, butyric, valeric, isovaleric and octanoic produced elevations in intracranial pressure during intravenous infusion in rabbits. Serum concentrations of these compounds are elevated in patients with Reye's syndrome, and may contribute to the intracranial pressure elevations found in these patients.

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