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Thiamine deficiency and cerebrospinal fluid 5-hydroxyindoleacetic acid: a preliminary study.
  1. M I Botez,
  2. S N Young,
  3. J Bachevalier,
  4. S Gauthier

    Abstract

    In three out of five patients with low cerebrospinal fluid thiamine concentrations, the 5-hydroxyindoleacetic acid (5HIAA) values also were low. All patients received thiamine replacement therapy; they underwent a second lumbar puncture after 13, 6, 7, 5 and 45 days of treatment. In all patients blood and cerebrospinal fluid thiamine values rose after treatment. In those patients with initially low CSF 5HIAA, thiamine treatment increased 5HIAA markedly.

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