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Localisation of malignant glioma by a radiolabelled human monoclonal antibody.
  1. J Phillips,
  2. T Alderson,
  3. K Sikora,
  4. J Watson
  1. Department of Neurosurgery, St. Laurence's Hospital, Dublin.


    Human monoclonal antibodies were produced by fusing intratumoral lymphocytes from patients with malignant gliomas with a human myeloma line. One antibody was selected for further study after screening for binding activity to glioma cell lines. The patient from whom it was derived developed recurrent glioma. 1 mg of antibody was purified, radiolabelled with 131I, and administered intravenously. The distribution of antibody was determined in the blood, CSF and tumour cyst fluid and compared with that of a control human monoclonal immunoglobulin. Antibody localisation in the tumour was observed and confirmed by external scintiscanning.

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