J Neurol Neurosurg Psychiatry 47:134-140 doi:10.1136/jnnp.47.2.134
  • Research Article

A retrospective study of Creutzfeldt-Jakob disease in England and Wales 1970-79. I: Clinical features.


A comprehensive search yielded 121 confirmed cases of Creutzfeldt-Jakob disease who died in England and Wales in the decade 1970-79, and 31 probable cases. The clinical features and the results of investigation are described. Three subgroups of patients were distinguished by clinical characteristics and contrasting course.