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"Therapeutic" serum concentration of phenytoin: the influence of seizure type.
  1. D M Turnbull,
  2. M D Rawlins,
  3. D Weightman,
  4. D W Chadwick

    Abstract

    Serum phenytoin concentrations were monitored prospectively in 26 patients with previously untreated partial epilepsy, during monotherapy with phenytoin. Only six remained entirely seizure-free, although only four experienced further tonic-clonic seizures. There was no correlation between serum phenytoin concentrations and freedom from partial seizures in those patients in whom such seizures recurred. There did appear to be a correlation between serum phenytoin concentration and freedom from tonic-clonic seizures.

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