Article Text


Phenytoin-induced increase in growth hormone response to levodopa in adult males.
  1. R D'Alessandro,
  2. P Cortelli,
  3. R Gallassi,
  4. E Ghisoli,
  5. N Montanaro,
  6. E Zoni,
  7. A Baruzzi


    Growth hormone and prolactin response to levodopa were evaluated before and after long-term phenytoin treatment in five men with previously untreated partial epilepsy. After phenytoin treatment, growth hormone response to levodopa increased. There was a close relationship between growth hormone response to levodopa and plasma phenytoin concentrations. These findings suggest a phenytoin-induced dopaminergic activity at the hypothalamic-pituitary level in adult males.

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