Article Text


Decreased platelet 3H-imipramine binding sites in classical migraine.
  1. D P Geaney,
  2. M G Rutterford,
  3. J M Elliott,
  4. M Schächter,
  5. K M Peet,
  6. D G Grahame-Smith


    Patients with classical migraine investigated between attacks had significantly fewer platelet 3H-imipramine binding sites than control subjects and this finding was more marked in males than in females. There was no abnormality of binding characteristics of platelet 5-hydroxytryptamine receptors or of platelet alpha 2-adrenoceptors. Because the reduced 3H-imipramine binding capacity was found in classical migraineurs who were investigated between attacks, it may reflect a predisposition to migraine rather than being a consequence of attacks.

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