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J Neurol Neurosurg Psychiatry 1985;48:1265-1268 doi:10.1136/jnnp.48.12.1265
  • Research Article

Laser injury of peripheral nerve: a model for focal endoneurial damage.

  1. R R Myers,
  2. H E James,
  3. H C Powell

      Abstract

      A model of endoneurial oedema is presented which produces localised nerve fibre injury including Wallerian degeneration, endoneurial oedema and increased endoneurial fluid pressure. A carbon dioxide laser was used to irradiate rat sciatic nerve and quantitative results were collected 2 days and 6 days after irradiation. The increase in endoneurial fluid pressure is compared with other models of Wallerian degeneration in which the entire fascicle was involved to aid in a comparative study of the role of oedema in neuropathy.

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