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Biochemical studies in mitochondrial encephalomyopathy.
  1. S Goda,
  2. S Ishimoto,
  3. I Goto,
  4. Y Kuroiwa,
  5. K Koike,
  6. M Koike,
  7. M Nakagawa,
  8. H Reichmann,
  9. S DiMauro
  1. Department of Neurology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

    Abstract

    The alpha-keto acid dehydrogenase complex and its component enzymes, lactate dehydrogenase, pyruvate carboxylase, cytochrome c oxidase, succinate-cytochrome c reductase, NADH-cytochrome c reductase, and the concentration of cytochromes and enzymes of beta-oxidation in muscle from a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes were studied and no specific defect was found. These results raise the possibility that the mitochondrial changes in the patient may be secondary.

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