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Late onset parkinsonian syndrome in Hallervorden-Spatz disease.
  1. R Alberca,
  2. E Rafel,
  3. I Chinchon,
  4. J Vadillo,
  5. A Navarro
  1. Department of Neurology, Ciudad Sanitaria Virgen del Rocĩo, Sevilla, Spain.

    Abstract

    Two siblings, from consanguineous parents, developed in their twenties a Parkinsonian syndrome. In the elder, the disease evolved for 13 years and the necropsic study was diagnostic of Hallervorden-Spatz disease. The younger sibling is severely affected after 12 years of the disorder. Several CT and one MR studies done in this patient during the last 4 years have been normal. Ultrastructural studies of the bone marrow histiocytes and blood lymphocytes disclosed peculiar inclusions. Bromocriptine in low doses proved to be a beneficial therapy for this patient.

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