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Controlled release levodopa treatment of motor fluctuations in Parkinson's disease.
  1. J L Juncos,
  2. G Fabbrini,
  3. M M Mouradian,
  4. C Serrati,
  5. A M Kask,
  6. T N Chase

    Abstract

    A controlled release preparation of levodopa-carbidopa, CR III, given every 4 hours to 17 Parkinsonian patients for up to 10 months reduced plasma drug variations and improved motor response fluctuations compared with standard levodopa-carbidopa given every 2 hours. The results support the value of pharmaceutical approaches to the stabilisation of circulating levodopa levels in the treatment of Parkinson's disease.

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