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Paradoxical effects of temperature in multiple sclerosis.
  1. W P Honan,
  2. J R Heron,
  3. D H Foster,
  4. R S Snelgar
  1. Department of Neurology, North Staffordshire Royal Infirmary, Stoke-on-Trent, UK.

    Abstract

    Six cases of multiple sclerosis are reported in which cold produced a temporary exacerbation of symptoms and signs of the disease. Also, in one case investigated in detail by psychophysical methods, heating produced a paradoxical deterioration in vision and simultaneous improvement in sensory and motor function. The effect of temperature in multiple sclerosis is discussed and a physiological explanation for the paradoxical response to heating is suggested.

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