Article Text

PDF

IgM monoclonal gammopathy and neuropathy in two siblings.
  1. T S Jensen,
  2. H D Schrøder,
  3. V Jønsson,
  4. J Ernerudh,
  5. B Stigsby,
  6. Z Kamieniecka,
  7. E Hippe,
  8. W Trojaborg
  1. Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.

    Abstract

    A sister and a brother with a progressive mixed axonal and demyelinating polyneuropathy were found to have a monoclonal IgM gammopathy of kappa and lambda type, respectively. Sural nerve and cutaneous nerve specimens obtained by biopsy showed deposits of IgM on myelin sheets. Sera from both patients contained antibodies directed to bovine peripheral nerve myelin as determined by ELISA technique and to normal human peripheral nerve myelin as demonstrated by indirect immunofluorescence histochemistry. These siblings may have a genetic predisposition to the formation of autoantibodies with peripheral nerve myelin as the target for the immune attack.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.