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J Neurol Neurosurg Psychiatry 1988;51:374-378 doi:10.1136/jnnp.51.3.374
  • Research Article

Adrenal cortex hormones in male epileptic patients before and during a 2-year phenytoin treatment.

  1. Z Ostrowska,
  2. B Buntner,
  3. D Rościszewska,
  4. I Guz
  1. Department of Pathophysiology, Silesian Medical Academy, Zabrze, Poland.

      Abstract

      Serum levels of progesterone, cortisol and phenytoin as well as the excretion of 17-OHCS were determined in 45 male epileptics before and during 24 months of the therapy. A significant decrease of the hormones was found in untreated patients. Phenytoin administration caused further decrease of cortisol and its metabolite 17-OHCS levels and a compensation of progesterone serum concentration.

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