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J Neurol Neurosurg Psychiatry 1988;51:773-777 doi:10.1136/jnnp.51.6.773
  • Research Article

Madras pattern of motor neuron disease in South India.

  1. M Gourie-Devi,
  2. T G Suresh
  1. Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.

      Abstract

      This paper presents the clinical features in 12 patients with the Madras pattern of motor neuron disease (MMND) seen over a period of 10 years. Ten of the patients were from other parts of South India, outside Madras. Young age at onset, sporadic occurrence, sensorineural deafness, bulbar palsy, diffuse atrophy with weakness of limbs and progressive but benign course were the striking features. Electromyography revealed chronic partial denervation. MMND formed 3.7% of all forms of motor neuron disease. Although isolated cases have been seen elsewhere in India, this is the first report of a large number of patients of MMND seen outside Madras (Tamil Nadu). Recognition of this clinical syndrome is of importance for prognostication and as well for search of possible aetiological factors.

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