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J Neurol Neurosurg Psychiatry 1989;52:338-340 doi:10.1136/jnnp.52.3.338
  • Research Article

Evoked potentials, reaction time and cognitive performance in on and off phases of Parkinson's disease.

  1. S E Starkstein,
  2. M Esteguy,
  3. M L Berthier,
  4. H Garcia,
  5. R Leiguarda
  1. Institute of Neurological Research, Dr. Paul Carrea, Buenos Aires, Argentina.

      Abstract

      Seven patients with Parkinson's disease and severe motor fluctuations were studied with event-related potentials, reaction and movement times and neuropsychological tests while in "off" and "on" phases. While there was a significant decrement in the P300 latency of the event-related potentials and in the duration of movement time in the "on" phase, no significant differences between on and off phases were observed in reaction time and neuropsychological tasks.

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