J Neurol Neurosurg Psychiatry 52:523-525 doi:10.1136/jnnp.52.4.523
  • Research Article

Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy?

  1. W T Asfora,
  2. A A DeSalles,
  3. M Abe,
  4. R N Kjellberg
  1. Department of Neurological Surgery, Massachusetts General Hospital, Harvard University, Boston.


      A case of angiographically occult brainstem vascular malformation presenting solely with pathological laughing and crying is reported. Although this emotional syndrome has been seen in association with several different pathological entities, review of the literature failed to identify its occurrence as the only clinical expression of angiographically occult brainstem vascular malformation, or as a solitary symptom in any disease. Our data suggest that pathological laughing and crying can occur without any other manifestation of pseudobulbar palsy. An attempt is made to correlate this patient's clinical and radiological findings. This case was treated by stereotactic Bragg-peak proton beam therapy.

      Visit the full archive of podcasts for JNNP here >>

      Free sample
      This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of JNNP.
      View free sample issue >>

      Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

      Navigate This Article