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J Neurol Neurosurg Psychiatry 1989;52:1006-1009 doi:10.1136/jnnp.52.8.1006
  • Research Article

Neuroleptic malignant syndrome: a case report with post-mortem brain and muscle pathology.

  1. E M Jones,
  2. A Dawson
  1. University of Bristol, UK.

      Abstract

      The neuroleptic malignant syndrome is a rare but dangerous complication of treatment with neuroleptics. The aetiology and pathophysiology of the syndrome are reviewed, and a fatal case is presented where both brain and muscle pathology are described. Striking myopathic changes in this case, accompanied by only minimal and non-specific brain abnormalities, support a peripheral rather than central mechanism for the hyperthermia.

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