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J Neurol Neurosurg Psychiatry 1990;53:854-855 doi:10.1136/jnnp.53.10.854
  • Research Article

Platelet monoamine oxidase B activity in parkinsonian patients.

  1. U Bonuccelli,
  2. P Piccini,
  3. P Del Dotto,
  4. G M Pacifici,
  5. G U Corsini,
  6. A Muratorio
  1. Institute of Clinical Neurology, University of Pisa, Italy.

      Abstract

      Monoamine oxidase B (MAO B) plays a pivotal role in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinsonism. An increased MAO B activity in platelets of patients with idiopathic Parkinson's disease (PD) is reported in this study. The possibility that high MAO B activity may represent a trait of vulnerability for PD by enhancing the neurotoxic effects of environmental compounds is discussed.

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