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High incidence of endogenous depression in migraine: confirmation by tyramine test.
  1. J Jarman,
  2. M Fernandez,
  3. P T Davies,
  4. V Glover,
  5. T J Steiner,
  6. C Thompson,
  7. F C Rose,
  8. M Sandler
  1. Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London, United Kingdom.

    Abstract

    Forty patients with migraine who were attending a specialist clinic were interviewed with the Schedule for Affective Disorders and Schizophrenia--Lifetime version. Sixteen (40%) had a history of major depression which was of endogenous type in 15, according to Research Diagnostic Criteria. The tyramine test, a previously established trait marker for endogenous depression, showed that the migraine group as a whole had significantly low values compared with 14 normal controls, due almost entirely to low values in the endogenous depressive subgroup; there were no differences between diet-sensitive and non-diet-sensitive migraine patients. Thus depression in patients with migraine seems unlikely to be secondary to migraine per se. A substantial subgroup of patients with migraine may possess an inherent predisposition to endogenous depression.

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