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Normal P300 following extensive damage to the left medial temporal lobe.
  1. M D Rugg,
  2. C D Pickles,
  3. D D Potter,
  4. R C Roberts
  1. Wellcome Brain Research Group, Department of Psychology, University of St Andrews, UK.

    Abstract

    Event-related potentials (ERPs) were recorded during auditory and visual "oddball" tasks from a patient with a severe verbal memory deficit due to a low grade infiltrating glioma which involved the full extent of the left medial temporal lobe. In both sensory modalities, the patient's oddball-evoked P300s were symmetrical and of normal amplitude. These findings are difficult to reconcile with the hypothesis that the hippocampus, or any other medial temporal structure, makes a substantial contribution to the scalp P300.

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