rss
J Neurol Neurosurg Psychiatry 1992;55:209-211 doi:10.1136/jnnp.55.3.209
  • Research Article

Neuropsychiatric manifestations of defect in mitochondrial beta oxidation response to riboflavin.

  1. W J Triggs,
  2. C R Roe,
  3. W J Rhead,
  4. S K Hanson,
  5. S N Lin,
  6. L J Willmore
  1. University of Texas Health Science Center, Department of Neurology, Houston.

      Abstract

      A 29 year old woman is described with severe hyperemesis gravidarum, atypical migraine, numerous admissions to hospital for psychiatric illness, non-epileptic seizures, and valproate-induced coma. Metabolic studies and measurement of [9,10(n)-3H]palmitate oxidation by cultured fibroblasts suggested a multiple acyl-CoA dehydrogenation disorder. Treatment with riboflavin abolished headaches and abnormal behaviour and normalised the plasma free carnitine level. Subtle defects in mitochondrial beta oxidation may be a treatable cause of disordered behaviour in adults.

      This Article

      1. Abstract
      2. PDF

      Responses

      1. Submit a response
      2. No responses published

      Register for free content

      The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

      Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

      BMJ Careers - Latest neurology and neurosurgery jobs