J Neurol Neurosurg Psychiatry 56:925-928 doi:10.1136/jnnp.56.8.925
  • Research Article

Vigabatrin and depression.

  1. H A Ring,
  2. R Crellin,
  3. S Kirker,
  4. E H Reynolds
  1. Department of Neurology, Maudsley Hospital, London.


      Ten patients who developed a major depressive episode in association with vigabatrin treatment for intractable epilepsy are reported. The depression usually occurred early in the course of treatment, but when delayed followed a recent increase in dose. Depressive symptoms occurred at doses varying between 1.5 g and 4 g a day, often but not always when patients were experiencing a decrease in their seizure frequency. Most patients had a history of affective disturbance, sometimes in association with other GABAergic drugs. The observations support a possible role for GABAergic mechanisms in the biology of mood disorders.