Two patients with unilateral spatial neglect caused by right frontal lobe lesions underwent cerebral blood flow studies. A 54-year-old, right-handed woman developed left hemiplegia and frontal lobe neglect associated with cerebral haemorrhage after surgical excision of a frontal tumour. A 66-year-old, right-handed woman developed a haemorrhage in the right frontal lobe caused by rupture of an aneurysm. This was followed by left hemiplegia and frontal lobe neglect. In both cases, 123I-iodoamphetamine single photon emission CT disclosed a reduction in regional cerebral blood flow localised along the circumference of the haematoma in the frontal lobe, but did not reveal any lesions in the parieto-occipital junction. These findings suggest that, in these two cases, the frontal lobe neglect was caused by lesions confined to the frontal lobe.
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