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Familial clustering of multiple sclerosis in a northern Swedish rural district.
  1. M Binzer,
  2. L Forsgren,
  3. G Holmgren,
  4. U Drugge,
  5. S Fredrikson
  1. Department of Neurology, University Hospital, Umeå, Sweden.

    Abstract

    A small rural district in the most northerly province of Sweden was found to have a very high occurrence of multiple sclerosis. A total of 12 patients with multiple sclerosis among 4744 inhabitants were identified (five females, seven males), corresponding to a prevalence of 253/100,000. Many of the patients were related and a further 21 cases with multiple sclerosis (14 females, seven males), mostly living in the neighbouring area, have family ties to the district. A genealogical investigation showed that 22 of the 33 patients identified had ties of kinship and thus, to our knowledge, the largest aggregation of multiple sclerosis in a family is presented.

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