Article Text

PDF

Treatment of multiple sclerosis with IVIg: potential effects and methodology of clinical trials.
  1. P S Sørensen
  1. Department of Neurology, National University Hospital, Copenhagen, Denmark.

    Abstract

    There is extensive evidence that immune mechanisms are involved in the pathogenesis of multiple sclerosis (MS). A potential treatment effect of IVIg in MS could be mediated by several mechanisms as IVIg is able to modulate the immune response in different ways. The evidence of the effect of IVIg in MS is at present based on the results of small open trials, some of which have been encouraging. Confirmation of a beneficial effect of IVIg must await the results of placebo-controlled, double-blind trials. A placebo-controlled, crossover study of IVIg is being conducted using magnetic resonance imaging (MRI) for monitoring disease activity. However, the ultimate proof of efficacy must come from studies of parallel groups with large numbers of patients followed for long periods with repeated clinical observations of neurological function, for example, the Expanded Disability Status Scale (EDSS) or the Neurological Rating Scale (NRS).

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.