J Neurol Neurosurg Psychiatry 59:185-188 doi:10.1136/jnnp.59.2.185
  • Research Article

Prospective study of relations between cortical Lewy bodies, poor eyesight, and hallucinations in Alzheimer's disease.

  1. R McShane,
  2. K Gedling,
  3. M Reading,
  4. B McDonald,
  5. M M Esiri,
  6. T Hope
  1. Department of Psychiatry of Old Age, Radcliffe Infirmary, Oxford, UK.


      The presence of hallucinations is included in some, but not all, of the sets of clinical diagnostic criteria that have been proposed for dementia associated with cortical Lewy bodies. These criteria were developed from retrospective casenote analyses. This prospective, longitudinal study suggests that, in patients with Alzheimer's disease, cortical Lewy bodies are associated with more persistent and severe hallucinations, independently of any association with severity of cognitive decline. Poor eyesight contributes to the severity but not the persistence of the hallucinations.