Panencephalopathic type of Creutzfeldt-Jakob disease associated with cadaveric dura mater graft

Neuropathological findings of necropsied cases of Creutzfeldt-Jakob disease (CJD) after cadaveric dura mater grafts

Case No and authors		Age (y) /sex		Clinical diagnosis		Codon 129^1-150		Brain weight (g)		Spongiform change	Kuru type amyloid plaques	Distribution of the lesions
Case No and authors		Age (y) /sex		Clinical diagnosis		Codon 129^1-150		Brain weight (g)		Spongiform change	Kuru type amyloid plaques	Cerebral cortex	Deep grey matter	White matter	Cerebellum
1 Miyashita et al ⁵	26/F	CJD	NE	920	+		+	+		+
2 Willison et al ⁶	30/M	CJD	NE		+		+	+		+
3 Pocchiari et al ⁷	32/F	CJD	Val/Val	950	+		+			+
4 Esmonde et al,⁸ case 2	44/F	CJD	NE		+	−	+	+		+
5 Lane et al ⁹	28/F	Idiopathic cerebellar degeneration	NE	1200	+	+	+	+	+	+
6 Yamadaet al ¹⁰	31/F	CJD	Met/Met	750	+	−	+	+	+	+
7 This case	52/M	CJD	Met/Met	760	+	−	+	+	+^1-151	+

↵1-150 Polymorphism at codon 129 of the prion protein gene. NE=Not examined.
↵1-151 Circumscribed spongy foci in the white matter as well as diffuse white matter changes.

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Panencephalopathic type of Creutzfeldt-Jakob disease associated with cadaveric dura mater graft

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