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REM sleep motor dysfunction in multiple system atrophy: with special emphasis on sleep talk as its early clinical manifestation
  1. N Tachibanaa,
  2. K Kimuraa,
  3. K Kitajimab,
  4. A Shindeb,
  5. J Kimurab,
  6. H Shibasakia
  1. aDepartment of Brain Pathophysiology, bDepartment of Neurology, Kyoto University School of Medicine, Kyoto, Japan
  1. Dr Naoko Tachibana, Department of Neuropsychiatry, Ehime University School of Medicine, Shigenobu-cho, Onsen-gun, Ehime, 791-02 Japan.

Abstract

Various neurodegenerative diseases involving brainstem structures as one of the main pathological lesions are reported to be associated with REM sleep behaviour disorder. Full blown REM sleep behaviour disorder can be diagnosed clinically, but REM sleep motor dysfunction, a pathophysiological basis of REM sleep behaviour disorder, is difficult to detect without all night polysomnography. Twenty one consecutive patients with multiple system atrophy with no complaints of nocturnal abnormal behaviours were clinically evaluated to determine the presence of sleep related symptoms. All night polysomnography with video monitoring was performed to investigate REM sleep characteristics and patients’ behaviours. In 85.7% (18 of 21) of the patients’ sleep talk started or increased around or after the clinical onset of the primary diseases. REM sleep without atonia occupied more than 15%(16.2%-100%) of the REM sleep time in all but one patient. In 90.5% (19 of 21) of patients, motor events such as sleep talk and various combinations of craniofacial, orofacial, or limb movements occurred at various frequencies mostly during REM sleep without atonia. In patients with multiple system atrophy, REM sleep motor dysfunction is a common polysomnographic finding which is otherwise overlooked, and sleep talk may be its early clinical manifestation.

  • multiple system atrophy
  • sleep talk
  • REM sleep behaviour disorder

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REM sleep without atonia, first described in experimental cats with bilateral lesions in the dorsolateral pontine tegmentum,1 was found to be associated with behavioural manifestations, ranging from REM sleep without atonia associated with no behavioural correlates to that with active locomotor disinhibition, depending on the location and size of the lesions.2Experimental cats with active locomotion along with violent behaviours have been considered an animal model for REM sleep behaviour disorder seen in neurological diseases with brainstem lesions.3-5Based on these experimental findings, we hypothesised that REM sleep motor dysfunction might occur even in patients with multiple system atrophy who do not report any nocturnal abnormal behaviours. Furthermore, by utilising all night polysomnography, the only method capable of detecting this kind of REM sleep abnormality that does not fulfill the criteria of REM sleep behaviour disorder, we aimed at elucidating how sleep related clinical symptoms are related to REM sleep motor dysfunction in patients with multiple system atrophy.

Patients and methods

PATIENTS

We studied 21 consecutive patients admitted to the Department of Neurology, Kyoto University Hospital with the diagnosis of multiple system atrophy (14 patients with sporadic olivopontocerebellar atrophy, six with Shy-Drager syndrome, and one with striatonigral degeneration) between July 1993 and January 1996 (table). All the patients were referred to us either for confirming the diagnosis or for seeking a second opinion, but not because of sleep related complaints. They were seven men and 14 women; mean (SD) age 60.5 (8.9) years, mean duration of disease 2.5 (range 0.5-10) years, and mean severity grade 1.8 (SD 1.1).6 The diagnosis was mainly based on the clinical features. None of them had a history of head injury, seizure disorder, psychiatric disorder, or alcohol or other drug misuse. All the patients were free of antiparkinsonian medication or psychoactive drugs for at least two weeks before the polysomnography studies.

METHODS

All patients and family members participated in the interview on their sleep history and sleep habit by using a structured sleep questionnaire. For each patient all night polysomnography recordings were performed using the standard technique in a secluded hospital room.7 EEG, electro-oculography (EOG), EMG (submental, tibialis anterior, and gastrocnemius muscles and other muscles as necessary) (figure), ECG, nasal and oral air flow, and chest and abdominal movements were recorded on a polygraph at a paper speed of 15 mm/s. Oxygen saturation was simultaneously monitored by pulse oxymetry. The patient was monitored with continuous audiovisual recording, and the ongoing behaviours and movements including sleep talk were charted. Videotapes were reviewed afterwards in reference to the polysomnography records.

Staging of waking and REM sleep was carried out according to standard criteria,7 and the modified version by Lapierre and Montplaisir was used for staging REM sleep and REM sleep without atonia as well as for defining phasic EMG events in the chin muscles.8 REM sleep without atonia was scored either when tonic EMG activity in the chin was present for 50% or more of a 20 s epoch or when the independent 2 s miniepochs containing the phasic submental EMG events occupied 50% or more of the 20 s epoch. Other determinants of REM sleep (cyclic temporal distribution, irregular breathing pattern, and appearance of saw toothed waves) and presence of segments with normal REM sleep were also considered to define REM sleep without atonia.

Sleep apnoea was defined as cessation of oral and nasal air flow during sleep, and hypopnoea as amplitude reduction of air flow by more than 50%, both lasting 10 s or longer. Sleep related oxygen desaturation was determined by dips in SaO2 by more than 4% from the overnight baseline SaO2.

Results

SLEEP RELATED SYMPTOMS

The table shows the main sleep related symptoms in the patients. No violent nocturnal behaviours were reported by family members. However, sleep talk started or increased around or after the onset of the primary diseases in 85.7% (18 of 21) of the patients, and in seven of them daily somniloquy was asserted by family members, who, however, did not consider it as a problem. Most of the patients reported sleep fragmentation or unrefreshing sleep and attributed it to frequent nocturia. Six patients identified as having excessive daytime sleepiness or daytime fatigue were either snorers or those with a complaint of sleep fragmentation secondary to nocturia. These sleep related symptoms did not correlate with either duration, severity, or predominant signs of the primary disease.

ALL NIGHT POLYSOMNOGRAPHY STUDY

REM sleep without atonia occupied more than 15% (mean (SD) 80.0 (27.1)%, range 16.2-100) of the total REM sleep time in all but one patient. In 90.5% (19 of 21) of patients various movements such as shaking or rotating the head, grimacing, teeth clenching, bruxing, chewing, throwing out or raising an arm, and waving a hand were seen, and in most patients these movements were associated with sleep talk ranging from uttering a word or mumbling to full sentences. These motor events were documented mostly during REM sleep without atonia, and never during non-REM sleep. They rarely occurred during REM sleep associated with chin muscle atonia, but some did appear when there were dense muscle twitches in the limb EMG. The movements of the limbs were not clearly purposeful or highly elaborated. Ambulatory behaviours such as sitting up or getting out of the bed were never seen, and no definite dream enacted behaviours occurred. The frequency of these motor events was variable, and did not correlate with either duration, severity, or predominant signs of the primary disease.

REM/REM sleep without atonia periods maintained their cyclic temporal distribution in 85.7% (18 of 21) of patients, and the mean (SD) number of REM periods was 2.5 (2.1) (range 1 to 5). In most cases REM sleep without atonia was characterised by continuous augmentation in chin muscle activity, often accompanied by phasic EMG discharges in the limbs, but on some occasions, independent but repetitive phasic EMG activations in the chin muscles were seen with or without muscle twitching in the limbs (fig 1).

Polygraphic record obtained from patient 6 with sporadic olivopontocerebellar atrophy. There is dense phasic activity in the chin EMG, and frequent EMG twitching in the limbs. Continuous hand movements were seen in the second half of this record. LOC and ROC=outer canthus of the left and right eye respectively; Thr=thorax; Abd=abdomen; SCM=sternocleidomastoid; FCR=flexor carpi radialis; ECR=extensor carpi radialis; APB=abductor pollicis brevis; TA=tibialis anterior; GC=gastrocnemius.

Although obstructive apnoea and hypopnoea were seen in 28.6% (6/21) of patients, none of the motor events was associated with transient arousals with resumption of breathing.

Discussion

None of our patients could be clinically diagnosed with REM sleep behaviour disorder according to the diagnostic criteria in the International Classification of Sleep Disorders,9 but REM sleep without atonia was seen in a high percentage of our patients with multiple system atrophy, and compared with the result obtained in normal elderly people,10 their percentage of REM sleep without atonia in total REM sleep time was abnormally high. REM sleep behaviour disorder-like phenomena were first anecdotally reported in sporadic olivopontocerebellar atrophy and Shy-Drager syndrome in the early 1980s,11-13 although called by different names. More recently Plazzi et al reported that 35 out of 39 patients with multiple system atrophy had REM sleep behaviour disorder based on polysomnographic recordings.5 The mean (SD) duration of the primary disease in their patients was longer (5 (3) years), and 15% of their patients were referred for prominent sleep related complaints. The findings of Plazzi et al and ours suggest that, even in patients with multiple system atrophy who are not clinically diagnosed with REM sleep behaviour disorder according to the current standard criteria, REM sleep motor dysfunction is commonly present. Although experimental lesion studies in cats suggest that REM sleep behaviour disorder and REM sleep motor dysfunction of various degrees comprise a range of the same pathophysiology,2 the mechanism underlying the generation of violent behaviours or minor movements in patients with REM sleep without atonia has not yet been clarified, and the reason why our patients did not present full blown REM sleep behaviour disorder is unknown. A longitudinal study including sleep diaries kept by family members as well as repeated polysomnographic recordings will be required to clarify this issue.

Another interesting clinical finding is that, in half of our patients, sleep talk began or increased in its frequency around or after the onset of the primary disease. There has been no systematic study about the incidence and frequency of sleep talk in the general population. Our patients and their families were questioned only retrospectively, which has a methodological limitation. As sleep talk is noticed much more easily by a bed partner or family members than the patients themselves, it might have been overestimated. In most of our patients, however, sleep talk during REM sleep without atonia was confirmed by the all night polysomnography, and various minor movements of the head, face, neck, and limbs were also simultaneously noted. Pathophysiological studies on sleep talk have been very scarce, but in one monograph, by Arkin,14 some of the presented polysomnographic features that had been recorded during sleep talk seem to be consistent with REM sleep without atonia, although the author named it “dissociated sleep stage”. The same kind of REM sleep motor dysfunction was reported in sleep talkers.15Therefore, the sleep talk noticed by the families of our patients with multiple system atrophy can be regarded as one of the manifestations of REM sleep motor dysfunction, although the physiology of independent sleep talk seen in otherwise healthy subjects might be various.14

MSA has brainstem lesions that interrupt the pontomedullary pathways mediating the REM sleep atonia anatomically and functionally, although REM sleep without atonia is not specific for multiple system atrophy.16 In addition, REM sleep behaviour disorder seen in familial fatal insomnia which is characterised by an isolated lesion of the anteroventral and dorsomedial thalamic nuclei suggests that the underlying mechanism of REM sleep without atonia may be heterogeneous.17 Neurologists have not been accustomed to systematically inquiring on the presence of sleep related symptoms, but increased or excessive sleep talk should be borne in mind as an early manifestation of REM sleep motor dysfunction in patients with multiple system atrophy.

Acknowledgments

We are grateful to Dr I Akiguchi for referring patients under his care, and to Dr H Fukuyama for MRI analysis. This research was supported by grants in aid for scientific research (A)06404031 and (A)08558083, for International Scientific Research 07044258, and for Scientific Research on Priority Areas 08279106 from the Japan Ministry of Education, Science, Sports and Culture, and a general research grant for aging and health from the Japan Ministry of Health and Welfare, all for HS.

References

Table 1

Sleep related symptoms as disclosed by the structured sleep questionnaire in 21 patients with MSA

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