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Decreased β-phenylethylamine in CSF in Parkinson’s disease
  1. Guang-xi Zhoua,
  2. Hiroshi Shojia,
  3. Shigeto Yamadab,
  4. Toyojiro Matsuishic
  1. aFirst Department (Neurology) of Internal Medicine, Kurume University School of Medicine, Kurume, Japan, bInsititute of Brain Diseases, Kurume University School of Medicine, Kurume, Japan, cDepartment of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan
  1. Dr Hiroshi Shoji, First Department (Neurology) of Internal Medicine, Kurume University School of Medicine , 67 Asahi-machi , Kurume , 830 Japan. Telephone 942 31 7560; fax 942 31 7703

Abstract

OBJECTIVE To determine the concentrations of β-phenylethylamine (PEA) in CSF in patients with Parkinson’s disease, and to evaluate the relation between concentration of PEA in CSF and severity of Parkinson’s disease.

METHODS Using gas chromatography-chemical ionisation mass spectrometry, CSF concentrations of PEA were measured in 23 patients with Parkinson’s disease (mean age, 64.0 (SD 8.2) years), of whom three were at Hoehn and Yahr stage II, 11 were at stage III, and nine were at stage IV. Comparison was made with eight patients with neuropathy (mean age, 57.0 (SD 19.2) years) and 12 controls without neurological disease (mean age, 57.6 (SD 4.8) years).

RESULTS Concentrations of PEA in CSF in Parkinson’s disease were significantly lower (mean 205 (SD 131) pg/ml) than in patients with peripheral neuropathy (433 (SD 254) pg/ml) and controls (387 (SD 194) pg/ml). The concentrations of PEA in CSF correlated negatively with Hoehn and Yahr stage (P<0.01).

CONCLUSIONS There are decreased CSF concentrations of PEA in patients with Parkinson’s disease.

  • β-phenylethylamine
  • cerebrospinal fluid
  • Parkinson’s disease
  • Hoehn and Yahr stage

https://doi.org/10.1136/jnnp.63.6.754

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