Upbeat nystagmus: clinicoanatomical correlation
- aDepartment of Neurology, St Mary’s Hospital, Praed Street, London, UK, bNeuro-otology Unit, MRC Human Movement and Balance Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
- Dr AJ Larner, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK. Fax 0044 171 829 8720.
- Received 31 October 1997
- Revised 28 January 1998
- Accepted 30 January 1998
Abstract
A patient is reported on with isolated upbeating nystagmus with a linear slow phase in whom a solitary lesion, probably inflammatory, was detected radiologically in the dorsal paramedian caudal medulla, encompassing the most caudal of the perihypoglossal nuclei, the nucleus intercalatus of Staderini. The conjunction of a vestibular pattern of nystagmus with this focal lesion runs contrary to a previous suggestion that the nucleus intercalatus may act as a neural integrator for vertical conjugate eye movements.
