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Oropharyngeal palsy in Guillain-Barré and Fisher’s syndromes is associated with muscle weakness in the neck and arm
  1. MICHIAKI KOGA,
  2. NOBUHIRO YUKI,
  3. KOICHI HIRATA
  1. Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
  1. Dr Michiaki Koga, Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321–0293, Japan. Tel: 0081 282 86 1111 extention 2733 or 2578; fax 0081 10-60-89313; email: koga{at}dokkyomed.ac.jp

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Guillain-Barré syndrome is an immune mediated peripheral neuropathy characterised by acute onset of symmetric limb weakness and areflexia. Patients with typical Guillain-Barré syndrome had greater leg weakness than arm weakness, with an ascending progression.1 Some patients with Guillain-Barré syndrome, however, present muscle weakness only at the oropharynx, neck, and proximal upper limb muscles, and a descending pattern of weakness appears as illness progresses.2Ropper2 proposed that the second group of patients had a variant of Guillain-Barré syndrome, “pharyngeal-cervical-brachial weakness (PCB)”. Ophthalmoplegia and cerebellar ataxia, however, are often noted in patients with PCB. Therefore, it is unclear whether PCB is an “atypical” Fisher’s syndrome or a distinct variant entity of Guillain-Barré syndrome. To clarify this, we investigated the relation of neck and limb weakness with cranial nerve involvements. We report here that oropharyngeal palsy in Guillain-Barré syndrome has a significant association with neck and …

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