Impairment of EEG desynchronisation before and during movement and its relation to bradykinesia in Parkinson’s disease
- aDepartment of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, bMRC Human Movement and Balance Unit, Institute of Neurology, Queen Square, London, UK, cThe National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
- Dr Peter Brown, The National Hospital for Neurology and Neurosurgery, and MRC Human Movement and Balance Unit, Institute of Neurology, Queen Square, London, UK. Telephone 0044 171 829 8759; fax 0044 171 278 9836.
- Received 14 August 1998
- Revised 9 November 1998
- Accepted 10 November 1998
Abstract
OBJECTIVE It has been suggested that the basal ganglia act to release cortical elements from idling (α) rhythms so that they may become coherent in the γ range, thereby binding together those distributed activities necessary for the effective selection and execution of a motor act. This hypothesis was tested in 10 patients with idiopathic Parkinson’s disease.
METHODS Surface EEG was recorded during self paced squeezing of the hand and elbow flexion performed separately, simultaneously, or sequentially. Recordings were made after overnight withdrawal of medication and, again, 1 hour after levodopa. The medication related improvement in EEG desynchronisation (in the 7.5–12.5 Hz band) over the 1 second before movement and during movement were separately correlated with the improvement in movement time for each electrode site. Correlation coefficients (r) > 0.632 were considered significant (p<0.05).
RESULTS Improvement in premovement desynchronisation correlated with reduction in bradykinesia over the contralateral sensorimotor cortex and supplementary motor area in flexion and squeeze, respectively. However, when both movements were combined either simultaneously or sequentially, this correlation shifted anteriorly, to areas overlying prefrontal cortex. Improvement in EEG desynchronisation during movement only correlated with reduction in bradykinesia in two tasks. Correlation was seen over the supplementary motor area during flexion, and central prefrontal and ipsilateral premotor areas during simultaneous flex and squeeze.
CONCLUSIONS The results are consistent with the idea that the basal ganglia liberate frontal cortex from idling rhythms, and that this effect is focused and specific in so far as it changes with the demands of the task. In particular, the effective selection and execution of more complex tasks is associated with changes over the prefrontal cortex.
