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Cerebrospinal fluid manganese concentrations in patients with symmetric pallidal hyperintensities on T1 weighted MRI
  1. T KATSURAGI,
  2. E ISEKI,
  3. K KOSAKA
  1. Department of Psychiatry, Yokohama City University School of Medicine, 3–9 Fukuura, Kanazawa-ku, Yokohama 236–0004, Japan
  2. Department of Neurology and Psychiatry, Kanagawa-ken Rehabilitation Center, 516 Nanasawa, Atsugi, Kanagawa 243–0121, Japan
  1. Dr T Katsuragi, Department of Psychiatry, Yokohama City University School of Medicine, 3–9 Fukuura, Kanazawa-ku, Yokohama 236–0004, Japan. Telephone 0081 45 787 2667; fax 0081 45 783 2540; email tk8041{at}med.yokohama-cu.ac.jp
  1. S KOYANO,
  2. K IWABUCHI
  1. Department of Psychiatry, Yokohama City University School of Medicine, 3–9 Fukuura, Kanazawa-ku, Yokohama 236–0004, Japan
  2. Department of Neurology and Psychiatry, Kanagawa-ken Rehabilitation Center, 516 Nanasawa, Atsugi, Kanagawa 243–0121, Japan
  1. Dr T Katsuragi, Department of Psychiatry, Yokohama City University School of Medicine, 3–9 Fukuura, Kanazawa-ku, Yokohama 236–0004, Japan. Telephone 0081 45 787 2667; fax 0081 45 783 2540; email tk8041{at}med.yokohama-cu.ac.jp

https://doi.org/10.1136/jnnp.66.4.551

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    Recently, there have been some reports that MRI shows characteristic brain lesions in patients with parenteral nutrition containing manganese (Mn), or hepatic failure, and that the serum or whole blood Mn concentration is often increased.1-3 T1 weighted MRI in these patients has shown hyperintensity, always in the bilateral globus pallidus and sometimes in part of the brainstem, although no abnormalities have been found on T2 weighted MRI. The Mn concentrations of CSF in these patients, however, have not been previously measured, because values in control subjects were previously undetermined. The present study was designed to investigate the CSF Mn concentrations in control subjects, and to evaluate the concentrations in patients with symmetric pallidal hyperintensities on T1 weighted MRI.

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    Serum, whole blood, and CSF Mn concentrations in five patients with hyperintensity on T1 weighted MRI and 10 control subjects without hyperintensity

    We examined five patients with the appropriate hyperintensity on T1 weighted MRI, aged from 31 to 72 years (mean 55.8 (SD 16.9) years); two with parenteral nutrition containing …

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