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Neurology and the gastrointestinal system
  1. Department of Medicine for the Elderly, Tameside General Hospital, Fountain Street, Ashton-under-Lyne OL6 9RW, UK

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    Neurology and the gastrointestinal system,1or an analysis of the “brain/gut” axis would be incomplete without allusion to the neuroendocrine system, and its mediation, via somatostatin, in the regulation of splanchnic blood flow and gastric acid secretion.2 3 These actions could account for the established haemostatic action of somatostatin in oesophageal variceal bleeding,4 and for the perception, derived from meta-analysis, that similar benefits might occur in non-variceal upper gastrointestinal haemorrhage.5 On the basis of the involvement of somatostatin in the regulation of gastric blood flow and acid secretion, it also seems reasonable to attribute gastric erosive bleeding, so-called Cushing’s ulcers, which occur in CNS disorders,6 to derangements in neuroendocrine pathways.


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