Right frontal lobe slow frequency repetitive transcranial magnetic stimulation (SF r-TMS) is an effective treatment for depression: a case-control pilot study of safety and efficacy
- aDepartment of Neurology, University of Louisville, 500 South Presyon Street, HSC 113, Louisville, KY 40202, USA, b60th MDOS/SGOMU, 101 Bodin Circle, Travis AFB, CA 94535, USA, c249 Ballindine Drive, Vacaville, CA 95688, USA
- Dr D L Menkes, Department of Neurology, University of Louisville, 500 South Presyon Street, HSC 113, Louisville, KY 40202, USA
- Received 17 July 1998
- Revised 23 December 1998
- Accepted 27 January 1999
Abstract
Major depression may result from decreased left frontal lobe function with respect to the right. Fast frequency repetitive transcranial magnetic stimulation (FF r-TMS) excites the underlying cortex whereas slow frequency repetitive transcranial magnetic stimulation (SF r-TMS) causes cortical inhibition. Left frontal FF r-TMS attenuates major depression whereas the inhibitory effects of right frontal SF r-TMS are unknown. This study tested the hypothesis that right frontal SF r-TMS would treat depressed patients with minimal effect on controls.
A psychiatrist administered the Beck depression inventory and Hamilton D depression rating scales to eight depressed patients and six controls before and after the treatment protocol. Eight sessions of 100 right frontal lobe SF r-TMS were given at motor threshold and 0.5 Hz over a 6 week period. No adverse outcomes were noted in either group. A significant antidepressant effect was noted in depressed patients on the Beck and Hamilton D depression rating scales (p<0.05). No change on either scale was noted in the controls. In conclusion right frontal lobe SF r-TMS is a safe, non-invasive treatment for major depression that deserves further investigation.
