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Neurological picture
Severe necrotising cutaneous lesions complicating treatment with interferon β-1a
  1. ALEXANDER J RADZIWILL
  1. Department of Neurology
  2. Department of Dermatology, University of Basel, Basel, Switzerland
  1. Dr Alexander J Radziwill, Department of Neurology, Kantonsspital, CH-4031 Basel, Switzerland.
  1. SALOME COURVOISIER
  1. Department of Neurology
  2. Department of Dermatology, University of Basel, Basel, Switzerland
  1. Dr Alexander J Radziwill, Department of Neurology, Kantonsspital, CH-4031 Basel, Switzerland.

https://doi.org/10.1136/jnnp.67.1.115

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    Subgroups of interferon-α (natural interferon-α, recombinant interferon α-1, recombinant interferon α-2a, recombinant interferon α-2b),1-3 recombinant interferon β-1b, and recombinant interferon-γ are known to produce severe necrotising cutaneous reactions.4 A 58 year old woman with an 11 year history of chronic inflammatory demyelinating polyneuropathy (CIDP) was treated by recombinant interferon β-1a (12 million units) subcutaneously three …

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